Used Lab Equipment

Includes Installation and One Year Warranty (Preventative Maintenance at 6 months)

Method Development and Training also Available

Includes:

• AB Sciex API 3200 Mass Spectrometer LC/MS/MS
• Windows 7 Computer loaded w/ Analyst Software 1.5
• Turbo V-Spray ESI
• Vacuum pump
• Shimadzu Prominence 20 UFLC  Shimadzu
• Shimadzu DGU-20A3 Degasser
• (2)Shimadzu LC_20AD Liquid Chromatograph
• Shimadzu CTO Column Oven
• Shimadzu CBM-20A Communication Module
• CTC Autosampler
• Monitor – Mouse – Keyboard
• Manuals

The API 3200 LC/MS/MS system is a fully-integrated triple quadrupole mass spectrometer built using premier technology that combines sensitivity and selectivity with ruggedness and reliability, all in an affordable, compact package

• Innovative Turbo V ion source efficiently ionizes compounds over a wide range of flow rates, virtually eliminating cross-contamination, even with large sample loads
• Patented LINAC collision cell technology delivers superior MS/MS performance allowing faster scan times without compromising sensitivity or mass spectral quality
• Simplifies cross-platform methods transfer
• Gives meaningful results from every experiment

Specifications:

• Detector type: Pulse Counting CEM
• Dynamic Range: 5 orders of magnitude
• Ionization Sources: TurboIonSpray, APCI, DuoSpray, PhotoSpray
• Mass Accuracy / Stability: 0.1 Da over 8 hours and 0.15 Da over 24 hours
• Mass Range: 5-1,700 (Quad); 50-1,700 (LIT)
• Polarity Switching Time: 700 ms
• Scan Speed (Quad): 24,000 Da/sec
• Scan Types: Q1 MS, Q3 MS, Product Ion, Precursor Ion, Neutral Loss or Gain, MRM, EMS, EPI, ER, MS3, TripleTrap

Innovative QJet ion guide technology dramatically improves sensitivity by capturing and focusing more ions generated by the efficient TURBO V ion source. And the TURBO V source virtually eliminates cross-contamination, even with high-concentration samples.  New innovations in sensitivity like QJet ion guide technology make it possible to reach the lowest limits of detection. Combining QJet ion guide technology with the proven TURBO V ion source and a powerful new generation of Analyst software results in a robust, high throughput platform ideal for all phases of pharmaceutical development.

Includes:

• AB Sciex API5000 LC/MS/MS
• Enhanced high performance triple quadrupole mass spectrometer system
• Line transformers
• Turbo V Ion Source (with APCI and ESI probes)
• Roughing Pump

• Windows 7 Computer loaded w/ Analyst Software 1.6

• Cart
• Agilent 1100 HPLC and CTC Autosampler
  • G1322 Degasser
  • G1312A Binary Pump
  • G1316A Column Compartment
  • G1323A Game Boy
  • CTC Autosampler

• Monitor – Mouse – Keyboard
• Cables and Manuals

Specifications:

• Detector type: Pulse-counting channel electron multiplier (CEM) detector
• Dynamic Range: 1 cps to 4 x 10(6) cps (pulse counting)
• Ionization Sources: ESI, APCI
• Mass Accuracy / Stability: 0.01% over the entire mass range
• Mass Range: 5 – 1250 m/z
• Scan Types:  Q1 MS, Q3 MS, Product Ion, Precursor Ion, Neutral Loss or Gain, MRM

Features:

The Jasco J-710 CD is a research grade instrument used for measuring the circular dichroism of compounds in solution, including small molecules, peptides and proteins. The instrument was purchased in 1995 and has recently been upgraded to a J-715. The system will accept a number of sample devices, but the default is a Peltier controlled thermostated cell holder designed for standard 1cm x 1cm quartz cuvettes. Spacers are included to accommodate smaller cuvettes. The use of long path length liquid or gas cells requires removing the Peltier device and should only be done by Instrument Services staff.

Specifications:

• Wavelength Accuracy:
  ±0.2 nm (at 163 to 180 nm)
  ±0.1 nm (at 180 to 250 nm)
  ±0.3 nm (at 250 to 500 nm)
  ±0.8 nm (at 500 to 800 nm)
  ±2.0 nm (at 800 to 1100 nm)
• Light source: air-cooled 150W lamp
• Detector: Head-on photomultiplier tube
• Dimensions: 1115 (W) x 570 (D) x 410 (H) mm
   
   

Waters Autopurification System Includes:

• 3100 Mass Detector
• 1525 Binary HPLC Pump (0-22.5 mL/min)
• System Fluidics Organizer (SFO)
• 515 Make-up Pump
• 2489 UV/Vis Detector
• 2767 Sample Manager
• Sogevac SV40 BI Vacuum Pump
• PC with MassLynx 4.1

Includes:

• Agilent 6890 Plus Gas Chromatograph
• 7683 100 Vial Autosampler with Injector Tower

• Agilent 5973
• Edwards RV3 Vacuum Pump
• Computer Loaded with Chemstation Software
• Monitor

Specifications:

Mass Spectrometer:  

• Mode (standard): EI
• Modes (optional): PCI, NCI EI with CI source
• Ion source type: 5 - 241.5 eV
• Ionization energy: 0 - 315 uA
• Ionization current: 100 - 350 'C
• Transfer line temperature: 150 - 300 'C
• Quadrupole temperature: 150 - 200 'C
• Mass filter: Monolithic hyperbolic quadrupole
• Mass filter protection: Entrance lens
• Mass range:6 - 800 amu
• Mass resolution: Unit mass adjustable by tune
• Mass axis stability: Better than 0.10 amu/ 48 h
• Detector: EM with replacement horn
• Dynamic range (electronic): 10e6
• Scan rate (electronic): 10,000 amu/s
• Write-to-disk: 8,000 amu/s
• SIM: 30 ions x 50 groups
• Pumping system: Turbomolecular pump
• Total flow: 2 mL/min (standard turbo)

Gas Chromatograph: 

• Automatic injector (optional): Automatic alignment, fast injection
• Liner replacement: Compatible with optional flip-top inlet sealing system
• Injector: Split-splitless (standard), others available
• Oven temperature: Ambient +4 - 450 'C
• Oven ramps / plateaus: 6-7
• Carrier gases: Helium, hydrogen, nitrogen, argon
• Electronic pnuematic control: Auto pressure regulation for split/splitless, septum purge
• Carrier gas control modes: Constant pressure and flow modes; pressure and flow programmable
• Pressure range: 0 - 100 psi (standard), 0 - 150 psi (optional) with 0.01 psi resolution, pressure and temperature corrected
• Retention-time locking:RTL ready
• Flow control: Compatible with optional microfluidics controller

Features:

The 7890A Gas Chromatograph (GC) System is one of the world’s most widely used GC system. It features accurate temperature controls and precise injection systems, plus enhanced Electronic Pneumatic Control (EPC) modules for the best retention times.

Includes:

• Agilent 7890A GC
• Agilent 5975 MSD
• Agilent 7693 ALS

This Bruker BioSpin Avance III HD 400 High Performance Digital NMR Spectrometer was never installed and is unused in storage.

Specifications:

Frequency Controller & Signal Generation Unit

• Basic configuration two channels frequency range each channel: 5–650 MHz each
• Number of numerically controlled oscillators per channel: 3
• Frequency resolution: < 0.005 Hz
• Phase resolution: < 0.006º
• Attenuation resolution / attenuation range: < 0.1 dB / 90 dB
• Amplitude modulation: > 90 dB
• Event time for digital setting of frequency, phase and amplitude, either individually or simultaneously: 25 ns
• Memory per channel e.g. for pulse shaping: >8 Mbyte
• Phase monotony over 90 dB amplitude setting range: < + / - 0.5 º

Timing Controller

• Pulse sequence parameter calculation: in real time
• Timing resolution / min. duration:5 / 25 ns
• Output bus for events and devices: 96-bit

Communication Protocol

• Fast Ethernet TCP / IP

Host Computer

• Operating system: Windows 7

Receiver:

• Bandwidth: up to 5 MHz

Digital Receiver Unit (DRU)

• Effective dynamic range of digitizer
• SW < 5 MHz: > 16-bit
• SW < 1 MHz: > 18-bit
• SW < 6 kHz: > 22-bit
• Data compression / digital filtering: on the fly
• Optimum real time digital filters: Yes

Quadrature Receiver (RXAD):

• Quadrature image peaks with digital quadrature detection: 0%

Description: The DO308 drying oven is ideal for accurate water determination of solid or viscous samples like:

• Substances that release water only at elevated temperatures such as plastics in powder or granular form
• Substances that cause side reactions with Karl Fischer reagent such as oxidizing inorganic salts
• Substances that cause problems in the titration vessel due to their consistency such as fibrous or pasty substances
• Substances that are poorly soluble or insoluble such as wool, dough, tar or coal

Specifications:

• Temperature range: 40 - 300 °C
• Temperature accuracy: ±5 °C (@300°C)
• Footprint housing: 256 x 180 mm
• Dimensions overall: 500 x 220 mm
• Voltage (auto selection): 100 ... 230 VAC   
• Max. power consumption: 450 W
• Height: 390 mm
• Weight: 9.1 kg
  
  

Features and Benefits

• Easy and fast manual handling - Easy handling for left and right handed operators. Sample exchange and sample transport into the heated zone of the oven is provided for by the simple transport system with a magnetic guide rod attached to the glass sample boat.
• Equilibrium conditions are quickly reached - The cold and the hot zone can be purged separately with dry carrier gas using a stopcock. Ambient moisture introduced during sample exchange or addition via the sleeve opening is quickly carried away. Therefore, a stable drift is reached within a short period of time.
• Enhanced operational safety - There is no need to remove the transfer tube from the titration cell after switching off the oven; just open the stopcock to avoid contamination of the oven due to underpressure. Different temperature ranges can be pre-programmed in one cycle. Safety is further improved by automatic shut down after the analysis is completed.
• Ready for use - All necessary parts including the drying unit with gas flow measurement are part of the standard delivery. If purging with dry air is desired, an optional air pump is available.

Features

• Small footprint
• Flexible sampling
• Comes with a CPU

Specifications:

• Spectral range: 7800 - 350 cm-1 optimized, mid-infrared KBr beamsplitter
• Signal-to-noise: 1 minute: 35,000 : 1 (peak to peak)
• Spectral resolution: better than 0.8 cm-1; better than 0.5 cm-1 using aperture
• Wavenumber precision: 0.001 cm-1 at 2000 cm-1
• Wavenumber accuracy: 0.05 cm-1 at 2000 cm-1
• Ordinate linearity (ASTM E1421): < 0.15% T deviation from 0.0% T
• Optics

• Detector: Fast recovery deuterated triglycine sulfate (DTGS) detector
• Source: Mid-infrared Ever-Glo; user replaceable from bottom plate
• Beamsplitter: KBr/Ge mid infrared optimized
• Laser: Temperature controlled solid-state Near-IR diode laser
• Power Supply: 100 - 240V, 50/60 Hz
• Depth: 10.9 in
• Electronics: USB 2.0 high-speed bidirectional communication to PC
• Dimensions (W x D x H): 35 x 28 x 26 cm

Description:

BaySpec’s RamSpec-HR dispersive 1064 nm benchtop Raman spectrometers are turn-key solutions designed for best-in-class performance and resolution for dispersive 1064 nm Raman spectroscopy, offering maximum fluorescence background suppression. The system is equipped with three dedicated, highly efficient VPG gratings and an innovative, deep-cooled InGaAs detector to produce high-resolution (4 cm-1) and high-quality dispersive 1064 Raman spectra with full spectral coverage (100-3200 cm-1). The rugged benchtop platform of the RamSpec™-HR is an ideal system to replace bulky, slow, expensive and hard-to-operate FT-Raman systems. Both direct sampling option and Raman fiber probe attachment option are available.

SENTERRA Raman Microscope combines numerous novel and patented features such as fluorescence removal and on-demand confocal depth profiling. The most important innovation is certainly its continuous calibration method, as it eliminates daily calibrations with external standards, providing you reliable, reproducible measurements.

Specifications:

• High wavenumber accuracy with SureCal
• All-in-one, compact, confocal design
• Removal of fluorescence background with Concave Rubberband Correction
• Confocal depth profiling with FlexFocus
• Up to 4 excitation lasers
• Computer controlled XYZ mapping stages with autofocus

Includes Installation and One year Service Contract

Includes:

• G1946D LC/MSD Mass Spectrometer Series SL
• Roughing Pump
• Optional Front end HPLC

Specifications

• Mass Range: 2-3000m/z
• Mass Accuracy: +/-.13 u within the calibrated mass range in scan mode
• Mass Axis Stability: +- 0.13 u over 8 hours
• Scan Speed:
  • 2500 u/s standard mode
  • 5250 u/s fast scan mode
• SIM Sensitivity:
  • ESI at 400 ul/min
  • APCI at 1000 ul/min
  • Selected ion monitoring of m/z 609.3
  • Positive ionization
  • Signal To Noise Ratio
  • Quantity: 1 pg reserpine 100:1 RMS (20:1 peak-to-peak)
• Scan Sensitivity:
  • ESI at 400 ul/min
  • APCI at 1000 ul/min
  • Scan range m/z 100-650
  • Scan speed 2500 u/s
  • Extracted ion at m/z 609.3
  • Positive ionization
  • Signal To Noise Ratio
  • Quantity: 50 pg reserpine 100:1 RMS (20:1 peak-to-peak)
• Multiple Signal Acquisition: Ability to cycle through four different acquisition modes on a scan-by-scan basis within a single run

Includes Computer Loaded with 4000 Series Explorer Software Version 3.5.

The 4800 MALDI TOF/TOF Analyzer is a next-generation tandem time-of-flight MS/MS system that gives you all the advantages of MALDI in a flexible, easy-to-use, ultra-high-performance mass spectrometer.

• OptiBeam™ on-axis laser provides ten times greater sensitivity to identify and quantitate low-abundance proteins in complex biological samples.
• High-resolution precursor ion selection, enabled by the QuanTIS precursor selector, lets you detect and identify peptides that other systems miss and makes it easier for you to interpret your data by simplifying MS/MS spectra.
• Ideal solution for high sensitivity putative protein biomarker identification and quantitation.
• Fully supports LC MALDI workflows, allowing you to mass analyze without the time constraints of LC.
• Simple experiment setup and fast mass analysis maximizes laboratory productivity.
• High-energy, information-rich fragmentation patterns unavailable on other instrument platforms enable you to analyze carbohydrates, lipids, and other biological components.

Identify and Quantitate Putative Protein Biomarkers with Confidence
The 4800 MALDI TOF/TOF analyzer offers a new level of sensitivity for identifying and quantifying low abundance putative protein biomarkers. Fully compatible with novel iTRAQ™ reagents, the 4800 analyzer provides the most direct path to protein biomarker discovery. An expanded dynamic range enables high confidence identification and quantitation of low-level putative protein biomarkers in complex matrices. Powerful, easy-to-use GPS Explorer™ provides simplified, automated workflows to get you more quickly from discovery to validation.

The Only MALDI TOF/TOF™ Analyzer with On-Axis Laser Irradiation
The 4800 Analyzer is the only MALDI TOF/TOF mass spectrometer with on-axis laser irradiation, enabling sensitivity in the attamole range. Proprietary source modeling algorithms enable low ppm mass detection across the MALDI plate.

Expand Workflows, Increase Throughput
Get the speed, stability, and reliability you need to expand your current experimental workflows and add statistical significance to your experimental results. Quickly and easily increase throughput using automation features that allow you to rapidly and confidently collect the MS/MS spectra that really matter —and not waste valuable resources acquiring and evaluating those that don't.

The Agilent 6420A Triple Quadrupole LC/MS System is equipped with performance specifications in Signal-to-Noise ratio and Instrument Detection Limit for routine analysis.

Specifications:

• MRM sensitivity Signal-to-Noise ratio (S/N) ESI positive: S/N > 6,000:1 Noise 1 × RMS
• MRM sensitivity Signal-to-Noise ratio (S/N) ESI negative: S/N > 2,000:1 Noise 1 × RMS
• MRM sensitivity Instrument Detection Limit (IDL) ESI positive: IDL < 60 fg
• MRM sensitivity Instrument Detection Limit (IDL) ESI negative: IDL < 60 fg
• Mass range: m/z 5 – 2,250
• Polarity switching: 30 ms
• Mass resolution (autotune):7 Da
• Mass resolution (manual tune):5 Da
• Mass accuracy:1 Da from 5 – 1,000 m/z; 0.01% from 1,000 – 2,000 m/z; 0.02% from 2,000 – 2,250 m/z
• Mass stability: < 0.1 Da in 24 h
• Dynamic range: > 6.0 × 106
• Scan modes: MS scan, MS/MS product ion scan, MRM, MS/MS neutral loss/gain scan and precursor ion scan, SIM
• Maximum scan rate: 12,500 Da/s
• Minimum MRM dwell time: 1 ms
• MRM transitions: 450 per time segment, > 40,000 ion transitions per method
• Dynamic MRM transitions: 4,000 ion transitions per method
• Triggered MRM transitions: Up to 10 MRM transitions (primary and secondary) for library search and compound confirmation
• Collision cell ion clearance: < 1 ms

Features:

• 1260 Infinity Binary Pump Clinical
• 1260 Infinity high perfomance degasser clinical edition
• 1260 Infinity high perfomrance autosampler clinical edition
• PEAK Nitrogen generator system

The Agilent 6460C Triple Quadrupole LC/MS System is equipped with Agilent Jet Stream Technology to enable enhanced sensitivity. The 6460 provides a fast and robust solution to simultaneously quantify, screen, and confirm analytes in the laboratory.

• Greater signal and reduced noise - Agilent Jet Stream technology uses super-heated nitrogen to improve ion generation and desolvation
• Efficient analysis – fast MRM speeds allow for analysis of over 100 overlapping compounds in a given retention time window
• Screen, confirm and quantify – Triggered MRM (tMRM) combines fast and sensitive MRM quantitation with the generation of a product ion spectrum for library searching and compound screening and confirmation
• Fast polarity switching for analysis of both positive and negative ions

Specifications:

• MRM sensitivity Signal-to-Noise ratio ESI positive: S/N > 30,000:1 Noise 1 × RMS
• MRM sensitivity Signal-to-Noise ratio (S/N) ESI negative: S/N > 10,000:1 Noise 1 × RMS
• MRM sensitivity Instrument Detection Limit (IDL) ESI positive: IDL < 12.5 fg
• MRM sensitivity Instrument Detection Limit (IDL) ESI negative: IDL < 12.5 fg
• Mass range: m/z 5 – 3,000
• Polarity switching: 30 ms
• Mass resolution (autotune):7 Da
• Mass resolution (manual tune):5 Da
• Mass accuracy:
  • Da from 5 – 1,000 m/z
  • 01% from 1,000 – 2,000 m/z
  • 02% from 2,000 – 3,000 m/z
• Mass stability: < 0.1 Da in 24 h
• Dynamic range: > 6.0 × 106
• Scan modes: MS scan, MS/MS product ion scan, MRM, MS/MS neutral loss/gain scan and precursor ion scan, SIM
• Maximum scan rate: 12,500 Da/s
• Minimum MRM dwell time: 1 ms
• MRM transitions: 450 per time segment > 40,000 ion transactions per method
• Dynamic MRM transitions: 4,000 ion transitions per method
• Triggered MRM transitions: Up to 10 MRM transitions (primary and secondary) for library search and compound confirmation
• Collision cell ion clearance: < 1 ms