Used Lab Equipment

Description: The DO308 drying oven is ideal for accurate water determination of solid or viscous samples like:

• Substances that release water only at elevated temperatures such as plastics in powder or granular form
• Substances that cause side reactions with Karl Fischer reagent such as oxidizing inorganic salts
• Substances that cause problems in the titration vessel due to their consistency such as fibrous or pasty substances
• Substances that are poorly soluble or insoluble such as wool, dough, tar or coal

Specifications:

• Temperature range: 40 - 300 °C
• Temperature accuracy: ±5 °C (@300°C)
• Footprint housing: 256 x 180 mm
• Dimensions overall: 500 x 220 mm
• Voltage (auto selection): 100 ... 230 VAC   
• Max. power consumption: 450 W
• Height: 390 mm
• Weight: 9.1 kg
  
  

Features and Benefits

• Easy and fast manual handling - Easy handling for left and right handed operators. Sample exchange and sample transport into the heated zone of the oven is provided for by the simple transport system with a magnetic guide rod attached to the glass sample boat.
• Equilibrium conditions are quickly reached - The cold and the hot zone can be purged separately with dry carrier gas using a stopcock. Ambient moisture introduced during sample exchange or addition via the sleeve opening is quickly carried away. Therefore, a stable drift is reached within a short period of time.
• Enhanced operational safety - There is no need to remove the transfer tube from the titration cell after switching off the oven; just open the stopcock to avoid contamination of the oven due to underpressure. Different temperature ranges can be pre-programmed in one cycle. Safety is further improved by automatic shut down after the analysis is completed.
• Ready for use - All necessary parts including the drying unit with gas flow measurement are part of the standard delivery. If purging with dry air is desired, an optional air pump is available.

Description: With its dedicated operator interchangeable measurement cells to accommodate many different sample types, the NIRFlex N-500 is a uniquely, flexible FT-NIR Spectrometer. Its Fourier Transform polarization technology guarantees the same superior performance across different environmental conditions; from laboratory to warehouse.

Specifications:

• Dimensions (W x D x H): 350 x 250 x 450 mm

• Spectral range: 800 - 2500 nm (if not specified differently for measuring cell)

• Resolution: 8 cm−1 (with boxcar apodization)

• Type of interferometer: Polarization interferometer with TeO2 wedges

• Wavenumber accuracy: ± 0.2 cm−1 (measured with HF gas cell at an ambient temperature of 25℃ ± 5℃)

• Signal-to-noise ratio: 10000 (peak-to-peak noise of a linear corrected baseline)

• Number of scans/sec.: 2 - 4 (depends on resolution)

• Type of lamp/lifetime lamp (MTBF): Tungsten halogen lamp / 12000 h (2 x 6000 h)

• Type of laser: 12 VDC HeNe, wavelength at 632.992 nm

• Analog digital converter: 24 bit

• Electric power supply: 100 - 230 VAC ± 10%, 50/60 Hz, 350 W

• Ethernet connection: 100 Mbit/s

Includes Installation and One Year Warranty (Preventative Maintenance at 6 months)

Method Development and Training also Available

Includes:

• AB Sciex API 3200 Mass Spectrometer LC/MS/MS
• Windows 7 Computer loaded w/ Analyst Software 1.5
• Turbo V-Spray ESI
• Vacuum pump
• Shimadzu Prominence 20 UFLC  Shimadzu
• Shimadzu DGU-20A3 Degasser
• (2)Shimadzu LC_20AD Liquid Chromatograph
• Shimadzu CTO Column Oven
• Shimadzu CBM-20A Communication Module
• CTC Autosampler
• Monitor – Mouse – Keyboard
• Manuals

The API 3200 LC/MS/MS system is a fully-integrated triple quadrupole mass spectrometer built using premier technology that combines sensitivity and selectivity with ruggedness and reliability, all in an affordable, compact package

• Innovative Turbo V ion source efficiently ionizes compounds over a wide range of flow rates, virtually eliminating cross-contamination, even with large sample loads
• Patented LINAC collision cell technology delivers superior MS/MS performance allowing faster scan times without compromising sensitivity or mass spectral quality
• Simplifies cross-platform methods transfer
• Gives meaningful results from every experiment

Specifications:

• Detector type: Pulse Counting CEM
• Dynamic Range: 5 orders of magnitude
• Ionization Sources: TurboIonSpray, APCI, DuoSpray, PhotoSpray
• Mass Accuracy / Stability: 0.1 Da over 8 hours and 0.15 Da over 24 hours
• Mass Range: 5-1,700 (Quad); 50-1,700 (LIT)
• Polarity Switching Time: 700 ms
• Scan Speed (Quad): 24,000 Da/sec
• Scan Types: Q1 MS, Q3 MS, Product Ion, Precursor Ion, Neutral Loss or Gain, MRM, EMS, EPI, ER, MS3, TripleTrap

Innovative QJet ion guide technology dramatically improves sensitivity by capturing and focusing more ions generated by the efficient TURBO V ion source. And the TURBO V source virtually eliminates cross-contamination, even with high-concentration samples.  New innovations in sensitivity like QJet ion guide technology make it possible to reach the lowest limits of detection. Combining QJet ion guide technology with the proven TURBO V ion source and a powerful new generation of Analyst software results in a robust, high throughput platform ideal for all phases of pharmaceutical development.

Includes:

• AB Sciex API5000 LC/MS/MS
• Enhanced high performance triple quadrupole mass spectrometer system
• Line transformers
• Turbo V Ion Source (with APCI and ESI probes)
• Roughing Pump

• Windows 7 Computer loaded w/ Analyst Software 1.6

• Cart
• Agilent 1100 HPLC and CTC Autosampler
  • G1322 Degasser
  • G1312A Binary Pump
  • G1316A Column Compartment
  • G1323A Game Boy
  • CTC Autosampler

• Monitor – Mouse – Keyboard
• Cables and Manuals

Specifications:

• Detector type: Pulse-counting channel electron multiplier (CEM) detector
• Dynamic Range: 1 cps to 4 x 10(6) cps (pulse counting)
• Ionization Sources: ESI, APCI
• Mass Accuracy / Stability: 0.01% over the entire mass range
• Mass Range: 5 – 1250 m/z
• Scan Types:  Q1 MS, Q3 MS, Product Ion, Precursor Ion, Neutral Loss or Gain, MRM

Features

• Small footprint
• Flexible sampling
• Comes with a CPU

Specifications:

• Spectral range: 7800 - 350 cm-1 optimized, mid-infrared KBr beamsplitter
• Signal-to-noise: 1 minute: 35,000 : 1 (peak to peak)
• Spectral resolution: better than 0.8 cm-1; better than 0.5 cm-1 using aperture
• Wavenumber precision: 0.001 cm-1 at 2000 cm-1
• Wavenumber accuracy: 0.05 cm-1 at 2000 cm-1
• Ordinate linearity (ASTM E1421): < 0.15% T deviation from 0.0% T
• Optics

• Detector: Fast recovery deuterated triglycine sulfate (DTGS) detector
• Source: Mid-infrared Ever-Glo; user replaceable from bottom plate
• Beamsplitter: KBr/Ge mid infrared optimized
• Laser: Temperature controlled solid-state Near-IR diode laser
• Power Supply: 100 - 240V, 50/60 Hz
• Depth: 10.9 in
• Electronics: USB 2.0 high-speed bidirectional communication to PC
• Dimensions (W x D x H): 35 x 28 x 26 cm

Description:

BaySpec’s RamSpec-HR dispersive 1064 nm benchtop Raman spectrometers are turn-key solutions designed for best-in-class performance and resolution for dispersive 1064 nm Raman spectroscopy, offering maximum fluorescence background suppression. The system is equipped with three dedicated, highly efficient VPG gratings and an innovative, deep-cooled InGaAs detector to produce high-resolution (4 cm-1) and high-quality dispersive 1064 Raman spectra with full spectral coverage (100-3200 cm-1). The rugged benchtop platform of the RamSpec™-HR is an ideal system to replace bulky, slow, expensive and hard-to-operate FT-Raman systems. Both direct sampling option and Raman fiber probe attachment option are available.

SENTERRA Raman Microscope combines numerous novel and patented features such as fluorescence removal and on-demand confocal depth profiling. The most important innovation is certainly its continuous calibration method, as it eliminates daily calibrations with external standards, providing you reliable, reproducible measurements.

Specifications:

• High wavenumber accuracy with SureCal
• All-in-one, compact, confocal design
• Removal of fluorescence background with Concave Rubberband Correction
• Confocal depth profiling with FlexFocus
• Up to 4 excitation lasers
• Computer controlled XYZ mapping stages with autofocus

Includes Installation and One year Service Contract

Includes:

• G1946D LC/MSD Mass Spectrometer Series SL
• Roughing Pump
• Optional Front end HPLC

Specifications

• Mass Range: 2-3000m/z
• Mass Accuracy: +/-.13 u within the calibrated mass range in scan mode
• Mass Axis Stability: +- 0.13 u over 8 hours
• Scan Speed:
  • 2500 u/s standard mode
  • 5250 u/s fast scan mode
• SIM Sensitivity:
  • ESI at 400 ul/min
  • APCI at 1000 ul/min
  • Selected ion monitoring of m/z 609.3
  • Positive ionization
  • Signal To Noise Ratio
  • Quantity: 1 pg reserpine 100:1 RMS (20:1 peak-to-peak)
• Scan Sensitivity:
  • ESI at 400 ul/min
  • APCI at 1000 ul/min
  • Scan range m/z 100-650
  • Scan speed 2500 u/s
  • Extracted ion at m/z 609.3
  • Positive ionization
  • Signal To Noise Ratio
  • Quantity: 50 pg reserpine 100:1 RMS (20:1 peak-to-peak)
• Multiple Signal Acquisition: Ability to cycle through four different acquisition modes on a scan-by-scan basis within a single run

Bruker AMX-300 Nuclear Magnetic Resonance Spectrometer with the "piano" style console and an unshielded Oxford 300MHz magnet. The magnet was de-energized about five years ago. All of the kits for moving the magnet are included.  

This is a 2-channel system with a solids accessory rack with high power 1H and X transmitters. Three probes included (plus a Doty solid state probe): a 5mm 1H inverse probe, a 10mm BB, and a standard bore magic angle solids probe (7 & 4mm stators).  

Includes Installation and One Year Warranty (Preventative Maintenance at 6 months)

Method Development and Training also Available

Includes:

• AB Sciex API 3200 Mass Spectrometer LC/MS/MS
• Windows 7 Computer loaded w/ Analyst Software 1.5
• Turbo V-Spray ESI
• Vacuum pump
• Shimadzu Prominence 20 UFLC  Shimadzu
• Shimadzu DGU-20A3 Degasser
• (2)Shimadzu LC_20AD Liquid Chromatograph
• Shimadzu CTO Column Oven
• Shimadzu CBM-20A Communication Module
• CTC Autosampler
• Monitor – Mouse – Keyboard
• Manuals

The API 3200 LC/MS/MS system is a fully-integrated triple quadrupole mass spectrometer built using premier technology that combines sensitivity and selectivity with ruggedness and reliability, all in an affordable, compact package

• Innovative Turbo V ion source efficiently ionizes compounds over a wide range of flow rates, virtually eliminating cross-contamination, even with large sample loads
• Patented LINAC collision cell technology delivers superior MS/MS performance allowing faster scan times without compromising sensitivity or mass spectral quality
• Simplifies cross-platform methods transfer
• Gives meaningful results from every experiment

Specifications:

• Detector type: Pulse Counting CEM
• Dynamic Range: 5 orders of magnitude
• Ionization Sources: TurboIonSpray, APCI, DuoSpray, PhotoSpray
• Mass Accuracy / Stability: 0.1 Da over 8 hours and 0.15 Da over 24 hours
• Mass Range: 5-1,700 (Quad); 50-1,700 (LIT)
• Polarity Switching Time: 700 ms
• Scan Speed (Quad): 24,000 Da/sec
• Scan Types: Q1 MS, Q3 MS, Product Ion, Precursor Ion, Neutral Loss or Gain, MRM, EMS, EPI, ER, MS3, TripleTrap

Includes Computer Loaded with 4000 Series Explorer Software Version 3.5.

The 4800 MALDI TOF/TOF Analyzer is a next-generation tandem time-of-flight MS/MS system that gives you all the advantages of MALDI in a flexible, easy-to-use, ultra-high-performance mass spectrometer.

• OptiBeam™ on-axis laser provides ten times greater sensitivity to identify and quantitate low-abundance proteins in complex biological samples.
• High-resolution precursor ion selection, enabled by the QuanTIS precursor selector, lets you detect and identify peptides that other systems miss and makes it easier for you to interpret your data by simplifying MS/MS spectra.
• Ideal solution for high sensitivity putative protein biomarker identification and quantitation.
• Fully supports LC MALDI workflows, allowing you to mass analyze without the time constraints of LC.
• Simple experiment setup and fast mass analysis maximizes laboratory productivity.
• High-energy, information-rich fragmentation patterns unavailable on other instrument platforms enable you to analyze carbohydrates, lipids, and other biological components.

Identify and Quantitate Putative Protein Biomarkers with Confidence
The 4800 MALDI TOF/TOF analyzer offers a new level of sensitivity for identifying and quantifying low abundance putative protein biomarkers. Fully compatible with novel iTRAQ™ reagents, the 4800 analyzer provides the most direct path to protein biomarker discovery. An expanded dynamic range enables high confidence identification and quantitation of low-level putative protein biomarkers in complex matrices. Powerful, easy-to-use GPS Explorer™ provides simplified, automated workflows to get you more quickly from discovery to validation.

The Only MALDI TOF/TOF™ Analyzer with On-Axis Laser Irradiation
The 4800 Analyzer is the only MALDI TOF/TOF mass spectrometer with on-axis laser irradiation, enabling sensitivity in the attamole range. Proprietary source modeling algorithms enable low ppm mass detection across the MALDI plate.

Expand Workflows, Increase Throughput
Get the speed, stability, and reliability you need to expand your current experimental workflows and add statistical significance to your experimental results. Quickly and easily increase throughput using automation features that allow you to rapidly and confidently collect the MS/MS spectra that really matter —and not waste valuable resources acquiring and evaluating those that don't.

Includes:

• NXR FT-Raman Accessory Module )1064 nm Laser)
• Raman InGaAs Detector
• Nicolet/Nexus Series Sample Compartment Cover
• 180 Degree Reflective Sample Comp Dual Motor Assembly
• Raman Capillary Tube Holder
• FT Raman MicroStage
• Computer Loaded w/ Atlus Software, and FTIR Software

Nicolet FT-IR spectrometers from Thermo Electron Corporation are the highest performance FT-IR systems available. While the spectrometer has the power to handle the most advanced research-level experiments, routine analyses are performed just as conveniently.  Every facet of the Nicolet FT-IR spectrometer has been engineered to facilitate sample handling, introduce options to scientists, and increase laboratory throughput.

Specifications:

• Spectral Range (Standard): 7800 – 350 cm^-1
• Spectral Range (Option, CsI Optics): 6400 – 200 cm^-1
• Spectral Range (Option, Extended-Range Optics): 11000 – 375 cm^-1
• Spectral Range (Option, Multi-Range Optics): 27000 – 15 cm^-1 (Standard)
• Optical Resolution: 09 cm^-1
• Peak-To-Peak Noise (1 minute scan): < 8.68 x 10^-6 AU** (50,000:1)
• RMS Noise (1 minute scan): < 1.95 x 10-6 AU**
• Ordinate Linearity: 07 %T
• Wavenumber Precision: 01 cm
• Slowest Linear Scan Velocity: 0.158 cm/sec
• Fastest Linear Scan Velocity: 33 cm/sec
• Number of Scan Velocities: 15
• Rapid Scan (Spectra/second @ 16 cm^-1, 16 cm^-1: 65, 95
• Throughput Increase in Turbo Mode (@ 3000 cm: 25%
• Liquid Nitrogen-Cooled Detector Hold Time: 18 hours

The Agilent/HP 6890N GC features electronic pneumatic control of all gas pressures and flows. On-board sensors automatically compensate for ambient temperature changes and barometric pressure differences to routinely achieve more accurate and reproducible results. EPC reduces re-calibration frequency and improves laboratory productivity. Designed to work seamlessly with the 6890N, the included 7683 Autosampler connects without a controller box or multiple power cords/outlets, and is packed with features including Agilent’s fast-injection technology.

Includes:

• FID Detectors (Flame Ionization Detectors) OPtional
• 7683 Autosampler (100 Vial Capacity)
• Computer Loaded with Chemstation Software
• Manuals and Cables

Features:

• Electronic Pressure Control on detector and injector
• Ambient temperature +4 °C to 450 °C
• Temperature set point resolution: 1 °C
• Supports 6 oven ramps with 7 plateaus, Negative ramps are allowed
• Overview: Laboratories worldwide are looking for a GC solution that delivers reliability, performance, and reproducible results, And nothing produces these benefits like the Agilent 6890N Network GC. By integrating leading-edge technologies with an emphasis on quality manufacturing processes, the 6890N will bring a work ethic to your laboratory that’s matched only by your own.
• Accomplish more with networking abilities

• Lets you share business and scientific data easily within a laboratory and across sites for fast and informed decision making.
• Incorporates local area network (LAN) technology as a standard feature, which makes it easy to link communication and control of multiple analytical instruments. With networking, you can work smarter, faster, and more economically.

• Increased Laboratory Efficiency: Clock-time programming allows you to set up runs for unattended operation whenever you want. The system can be ready to work when you get to your laboratory. Pre-run and post-run commands automatically prepare the system for the next sample.
• Decreased Calibration Time: You can manually enter existing calibration data and make a run with just one standard peak. The system can normalize the calibration table for you, allowing you to cut calibration time and avoid re-running your calibration standards.
• High Sample Throughput: The 6890N network GC system is already set up for the Agilent 7683 automatic liquid sampler, enabling fast and easy installation. Single or dual injectors, equipped with either an 8-sample turret or a 100-vial sample tray, allow unattended operation. Using the 11-vial transfer turret with the tray and the solvent saving mode, you have enough solvent to run unattended eight times longer than before.
• Minimal Rework: The Agilent 6890N network GC system is the only GC system that automatically selects the optimum pressure-control mode for split and splitless analyses. Forward-pressure control is best for splitless injections. Along with a large inlet liner volume and pressure-pulse operation, this mode reduces discrimination, sample degradation, and sample loss caused by liner overload while maximizing sensitivity. For split injections, the system automatically selects back-pressure control for linear split ratios over the entire usable split-ratio range and over wide column flow and pressure ranges. This reduces sample preparation and increases reproducibility and accuracy. Automatic switching between forward-and back-pressure modes yields optimal results in less time and with less effort.

Specifications:

• Automatic injector (optional): Automatic alignment, fast injection
• Liner replacement: Compatible with optional flip-top inlet sealing system
• Injector: Split-splitless (standard), others available
• Oven temperature: Ambient +4 - 450 'C
• Oven ramps / plateaus: 6-7
• Carrier gases: Helium, hydrogen, nitrogen, argon
• Electronic pnuematic control: Auto pressure regulation for split/splitless, septum purge
• Carrier gas control modes: Constant pressure and flow modes; pressure and flow programmable
• Pressure range: 0 - 100 psi (standard), 0 - 150 psi (optional) with 0.01 psi resolution, pressure and temperature corrected
• Retention-time locking:RTL ready
• Flow control: Compatible with optional microfluidics controller
• Height: 50 cm (19.7 in.)

• Width: 58 cm (26.8 in.)
• Depth: 54 cm (21.6 in.)
• Average Weight: 49 kg (108 lb)
• Networkable: Yes
• Ambient Operating Temperature: 15 ËšC to 35 ËšC
• Ambient Operating Humidity: 5-95 %
• Storage Extremes: -40ËšC to 65Ëš
• Line Voltage Requirements: ±5% of nominal
• Dimensions: 28 x 31 x 16 cm
• Operating temperature: 4ËšC above ambient to 450ËšC
• Maximum run time: 120ËšC/min

Includes:

• Agilent 6890 Plus Gas Chromatograph
• 7683 100 Vial Autosampler with Injector Tower

• Agilent 5973
• Edwards RV3 Vacuum Pump
• Computer Loaded with Chemstation Software
• Monitor

Specifications:

Mass Spectrometer:  

• Mode (standard): EI
• Modes (optional): PCI, NCI EI with CI source
• Ion source type: 5 - 241.5 eV
• Ionization energy: 0 - 315 uA
• Ionization current: 100 - 350 'C
• Transfer line temperature: 150 - 300 'C
• Quadrupole temperature: 150 - 200 'C
• Mass filter: Monolithic hyperbolic quadrupole
• Mass filter protection: Entrance lens
• Mass range:6 - 800 amu
• Mass resolution: Unit mass adjustable by tune
• Mass axis stability: Better than 0.10 amu/ 48 h
• Detector: EM with replacement horn
• Dynamic range (electronic): 10e6
• Scan rate (electronic): 10,000 amu/s
• Write-to-disk: 8,000 amu/s
• SIM: 30 ions x 50 groups
• Pumping system: Turbomolecular pump
• Total flow: 2 mL/min (standard turbo)

Gas Chromatograph: 

• Automatic injector (optional): Automatic alignment, fast injection
• Liner replacement: Compatible with optional flip-top inlet sealing system
• Injector: Split-splitless (standard), others available
• Oven temperature: Ambient +4 - 450 'C
• Oven ramps / plateaus: 6-7
• Carrier gases: Helium, hydrogen, nitrogen, argon
• Electronic pnuematic control: Auto pressure regulation for split/splitless, septum purge
• Carrier gas control modes: Constant pressure and flow modes; pressure and flow programmable
• Pressure range: 0 - 100 psi (standard), 0 - 150 psi (optional) with 0.01 psi resolution, pressure and temperature corrected
• Retention-time locking:RTL ready
• Flow control: Compatible with optional microfluidics controller

Includes 1 year Service Contract, Installation, and a PM at 6 months

Developed for integrated UPLC/MS/MS quantitative applications, the Waters ACQUITY TQD features the highest levels of tandem quadrupole MS selectivity, robustness, speed, and accuracy.   To maximize the analytical advantages of UltraPerformance LC (UPLC), the ACQUITY TQD operates at the highest data acquisition rates. When integrated with the ACQUITY UPLC System, the ACQUITY TQD gives you class-leading analytical detection limits, resolution, and sample throughput for all of your quantitative applications: bioanalysis, ADME screening, food safety, environmental monitoring, clinical, forensic, and more.

Includes:

• Waters TQD UPLC/MS/MS Mass Spectrometer
• Enhanced high performance triple quadrupole mass spectrometer system
• Roughing Pump
• Windows 7 Computer loaded w/ Mass Lynx 4.1 SCN 805.IVD
• Flex Cart for UPLC
• Optional Waters Acquity
• Monitor – Mouse – Keyboard
• Cables and Manuals

Performance Specifications:

• Acquisition modes
  • Full scan MS
  • Product ion scan
  • Precursor ion scan
  • Constant neutral loss
  • Selected Ion Recording (SIR)
  • Multiple Reaction Monitoring (MRM)
• Survey scan modes: Full scan MS triggered product ion scan
• Mass range: 2 to 2048 m/z
• Scan speed: Up to 10,000 Da/s
• Examples of achievable acquisition rates:
  • 10 scans per second (m/z 100 to 1000)
  • 20 scans per second (m/z 50 to 500)
• Mass stability: Mass drift is < 0.1 Da over a 24 hour period
• Linearity of response: The linearity of response relative to sample concentration for a specified compound is five orders of magnitude from the limit of detection
• Polarity switching time: 20 ms to switch between positive and negat ive ion modes
• MRM acquisition rate: Minimum dwell time of 3 ms per MRM channel
• Inter-channel cross talk: The inter-channel cross talk between two MRM transitions, acquired using an MRM dwell time of 10 ms and an inter-channel delay time of 10 ms, will be less than 0.02%.
• Number of MRM channels: Up to 16,384 MRM channels (512 functions, 32 channels per function) can be monitored in a single acquisition; up to 1024 MRM channels when operating in GLP/secure mode (32 functions, 32 channels per function).
• Mass resolution: Automatically adjusted (InteUiStart) to desired resolu tion; The vaUey between the 2034.63 Da and 2035.63 Da peaks is < 12% of the average height of the two peaks
• MRM sensitivity (ESI+) : A 1 pg on-column injection of reserpine will give a chromatographic signal-ta-noise greater than 2,000:1 (Gradient separation, LC mobile phase flow rate of 0.8 mL/min, MRM transition mil 609 > 195).
• MRM sensitivity (ESI-): A five pg loop injection of chloramphenicol, wi th a mobile phase flow rate of 200 ~lImin will give a chromatographic signal-ta-noise for the transition 321 > 152 mlz greater than 180: 1.
• MRM sensitivity (APCI+): A 100 pg loop injection of 17-a-hydroxyprogesterone, with a mobile phase flow rate of 1000 IJLlmin will give a chromatographic signal-ta-noise for the transition 331 > 109 mil > 150:1.